Bjarke Feenstra

Bjarke Feenstra

Kontakt

Bjarke Feenstra, Sektionsleder, Genetisk epidemiologi
T. 32683852 @. fee@ssi.dk

Research Areas

I am interested in understanding how genetic variation affects health and disease with a focus on pregnancy-related outcomes (birthweight and gestational duration) and selected childhood diseases. I often use the genome-wide association study (GWAS) approach, but my projects also include other types of data, such as metabolomics profiles. In terms of childhood diseases, I am particularly interested in 1) the gastrointestinal disorder pyloric stenosis, and 2) febrile seizures.


Educations  
2006  PhD in Statistical Genetics. The Royal Veterinary and Agricultural University of Denmark  
2002  MSc in Biology and Statistics. University of Copenhagen. 
1997  BSc in Biology. University of Copenhagen  

Employments   
2011- Senior Researcher, Dept. of Epidemiology Research, SSI 
2007-2011   Research Scientist, Dept. of Epidemiology Research, SSI  
2006-2007   Research Scientist, Dept. of Statistics, deCODE genetics, Iceland 
2004-2005   Visiting Scientist, Dept. of Biostatistics, Johns Hopkins University, Baltimore (4 months)  
2003-2005  Statistics Instructor. The Royal Veterinary and Agricultural University of Denmark. 
2002  Visiting Research Assistant, Dept. of Biostatistics, Columbia University, New York (6 months) 
1999-2001  Assistant Editor of Biology, Danish National Encyclopedia 

Professional Activities and Leadership Positions 
2016-  Research Group Leader, Dept. of Epidemiology Research, SSI.  
2007-  Project leadership on numerous GWAS projects.  

Prizes and Honours 
2012  The Thorvald Madsen Prize  

International Collaborations 

A number of collaborative projects with the Early Growth Genetics (EGG) consortium and the iPSYCH consortium. Many international collaborations, e.g., for replication of genetic association findings or functional follow-up experiments.

 

Selected, recent publications
Liu X, Helenius D, Skotte L, …, Buil A, Feenstra B. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration. bioRxiv 2018; 423897, https://doi.org/10.1101/423897 
Fadista J, Skotte L, …, Feenstra B. Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis. Human Molecular Genetics 2018; ddy347, https://doi.org/10.1093/hmg/ddy347  
Beaumont RN, Warrington NM, …, Evans DM*, Lawlor DA*, Feenstra B*, Freathy RM*. Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics 2018; 27, 742-756, https://doi.org/10.1093/hmg/ddx429 *Shared last author  
Zhang G, Feenstra B, …, Muglia LJ. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal of Medicine 2017; 377, 1156-
1167, https://doi.org/10.1056/NEJMoa1612665 
Feenstra B, …, Hviid A. Common variants associated with general and MMR vaccine-related febrile seizures. Nature Genetics 2014; 46: 1274-1282, https://doi.org/10.1038/ng.3129