Dennis Christensen

Dennis Christensen

Kontakt

Dennis Christensen, Projektleder, Afdeling for Infektionsimmunologi / Adjuvans
T. 32683804 @. den@ssi.dk

 

Forskningsområder

Design og karakterisering af nye vaccineadjuvanser til profylaktiske såvel som therapeutiske vacciner. Brugen og karakterisering af liposombaserede deliverysystemer til vaccineantigener og immunstimulatorer. Undersøgelse af hvordan forskellige fysisk-kemiske egenskaber hos liposomer og vaccineantigener samt valget af administrationsrute påvirker immunsvaret.

Ansvarsområder

  • Leder af vaccineadjuvansforskning
  • Ansvarlig for eksterne samarbejder

Udvalgte publikationer

  • Christensen D, Hansen L.B, Leboux R, Jiskoot W, Christensen J.P, Andersen P and Dietrich J. A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization.  ACS Nano. 2019; DOI: 10.1021/acsnano.8b05209.
  • Schmidt S.T, Pedersen G.K, Neustrup M.A, Korsholm K.S, Rades T, Andersen P, Foged C, Christensen D. Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C). Frontiers in Immunology. 2018; 9:898.
  • Pedersen G.K, Andersen P, Christensen D. Immunocorrelates of CAF family adjuvants. Seminars in Immunology. 2018; 39: DOI: 10.1016/j.smim.2018.10.003.
  • Christensen D, Christensen J.P, Korsholm K.S, Isling L.K, Erneholm K, Thomsen A.R, Andersen P. Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Frontiers in Immunology. 2018; 8:1928.
  • Schmidt S.T, Khadke S, Korsholm K.S, Perrie Y, Rades T, Andersen P, Foged C, Christensen D. The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile. Journal of Controlled Release. 2016; 239:107-117.

Researchgate-link

Komplet publikationsliste: http://www.researchgate.net/profile/Dennis_Christensen2