Rasmus Krøger Hare

Forskningsområder

• Udvikling af molekylær diagnostik inden for medicinsk mykologi
  • PCR analyser: Aspergillus, Mucorales, Fusarium, Candida, dermatofytter og en pan-svampe PCR
• Molekylære resistensmekanismer i patogene svampe
  • Azolresistens i Aspergillus fumigatus samt andre Aspergillus spp.
  • Echinocandin- og azoleresistens i Candida, primært i Candida albicans, C. glabrata og C. tropicalis.
• Genotypning/helgenomsekventering
  • A. fumigatus
  • C. albicans, C. glabrata, C. tropicalis, C. parapsilosis og andre.

Priser

• ESCMID Research Grant 2013 (18,150 €)
• Københavns Universitets rejselegat 2012 (4,000 €)
• ECCMID rejselegat 2011 (1,200 €)
• Novo Scholarship 2008 (9,650 €)

PubMed link

Rasmus Krøger Hare - PubMed

Rasmus Krøger Hare - ORCID

Ansvarsområder

• Molekylær diagnostik inden for svampeinfektioner. Forskning, udvikling og kvalitetssikring. 
• Molekylære resistensmekanismer i patogene gær og skimler (Candida og Aspergillus).
• Molekylær identification samt genotypning af gær og skimler. 
• Identifikation af gær og skimmel ved MALDI-TOF MS
• Serumkoncentrationsmåling af svampemidler (voriconazole, isavuconazole, itraconazole, posaconazole og 5-Flucytosin ved uHPLC).
• Bestyrelsesmedlem og webmaster for Nordic Society of Medical Mycology (NSMM)

Publikationer

1. Jensen RH. Resistance in human pathogenic yeasts and filamentous fungi: prevalence, underlying molecular mechanisms and link to the use of antifungals in humans and the environment. Dan Med J. 2016; 63 (10). http://www.ncbi.nlm.nih.gov/pubmed/27697142 (PubMed ID: 27697142)
2. Jensen RH, Hagen F, Astvad KMT, Tyron A, Meis JF, Arendrup MC. Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes. Clin Microbiol Infect. 2016; 22 (6):570.e1-9. http://linkinghub.elsevier.com/retrieve/pii/S1198743X16300581 (PubMed ID: 27091095)
3. Jensen RH, Johansen HK, Søes LM, Lemming LE, Rosenvinge FS, Nielsen L, et al. Posttreatment Antifungal Resistance among Colonizing Candida Isolates in Candidemia Patients: Results from a Systematic Multicenter Study. Antimicrob Agents Chemother. 2016; 60 (3):1500–8. http://aac.asm.org/lookup/doi/10.1128/AAC.01763-15 (PubMed ID: 26711776)
4. Jensen RH, Astvad KMT, Silva LV, Sanglard D, Jørgensen R, Nielsen KF, et al. Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations. J Antimicrob Chemother. 2015; 70 (9):2551–5. http://www.jac.oxfordjournals.org/cgi/doi/10.1093/jac/dkv140 (PubMed ID: 26017038)
5. Jensen RH, Arendrup MC. Candida palmioleophila: Characterization of a Previously Overlooked Pathogen and Its Unique Susceptibility Profile in Comparison with Five Related Species. J Clin Microbiol. 2011; 49 (2):549–56. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3043495&tool=pmcentrez&rendertype=abstract (PubMed ID: 21147953).