Mads Melbye

Mads Melbye

Kontakt

Mads Melbye , Direktør , Statens Serum Institut
T. 32683163 @. mme@ssi.dk

 

Forskning

Forskningsinteresser omfatter infektionsepidemiologi, vaccineeffekter, genetisk disponering for sygdom, perinatal epidemiologi og kræftepidemiologi. 
Mads Melbye har stor erfaring med forskning baseret på de danske registre og biobanker.

Publikationer

Mads Melbye har skrevet mere end 590 videnskabelige artikler og har et H-index på 85 i Web of Science og 105 i Google Scholar.

Komplet publikationsliste


Uddannelse
1988 Dr.med.
1984 Lægevidenskabelig embedseksamen

Karriere
2016- Administrerende direktør, SSI
2014- Professor i Medicinsk Epidemiologi, Københavns Universitet (10%)
2013- Consulting Professor, Stanford University School of Medicine
1992- Afdelingschef, Afd. for Epidemiologisk Forskning, SSI
2015-16 Direktør, Sektor for Epidemiologi og Smitteberedskab, SSI
2012-15 Direktør, Sektor for National Sundhedsdokumentation og Forskning, SSI
2004-12 Direktør, Sektor for Epidemiologi, SSI
1998-2008 Adjungeret Professor, Karolinska Institutet, Stockholm
1998-2002 NorFA-professor
1992-97 Forskningsrådsprofessor (udnævnt til 'Superprofessor' af Uddannelsesminister Bertel Haarder
1991-92 Statsepidemiolog, Epidemiologisk afd., SSI
1988-91 Seniorforsker, Institut for Kræftepidemiologi, Kræftens Bekæmpelse
1986-88 Introduktionsstilling i intern medicin, Aarhus Universitetshospital og Rigshospitalet
1985-86 Gæsteforsker, Environmental Epidemiology Branch, National Cancer Institute, NIH
1984-85 Videnskabelig assistent, Institut for Kræftforskning, Aarhus

Bestyrelses- og tillidsposter (udvalgte)
2018- Medlem, Biobank Sweden's Scientific Advisory Board
2017- Bestyrelsesformand, WHO's International Agency for Research on Cancer (IARC), Lyon, Frankrig
2014- Medlem, International Scientific Advisory Board, UK Biobank
2011- Medlem af Fonden til Lægevidenskabens Fremme, AP Møller og hustru Chastine Mc-Kinney Møllers Fond
2005- Formand for den videnskabelige komité, Helsefonden
2012-14 Formand, WHO's Board of Scientific Councillors, International Agency for Research on Cancer (IARC), Lyon, Frankrig
2007-17  Medlem af Novo Nordisk Priskomitéen
2007-10 Formand for styregruppen for de nordiske forskningsråd (NOS-M)
2006-10 Næstformand, Statens Sundhedsvidenskabelige Forskningsråd
2004-06 Medlem af Statens Sundhedsvidenskabelige Forskningsråd
2002-12 Formand, Ministeriet for Videnskab, Teknologi og Innovations koordinerede organ for 
registerforskning (KOR)
2000-01 Formand, Forsknings- og Teknologiministeriets registerforskningsudvalg

Priser
2014 Erhoff-prisen
2005 Novo Nordisk Prisen
1998 Thorvald Madsen Prisen
1993 Ipsen forelæsning
1992 Anders Jahre Prisen for yngre forskere, Oslo, Norge
1989 AIDS fondens pris
1985 Hjortenberg Foundation Prize
1983 Guldmedaljen ved Aarhus Universitet for afhandling om mikrobiologi og onkologi

Udvalgte publikationer
Husby A, Wohlfahrt J, Melbye M. Pregnancy duration and breast cancer risk. Nat Commun 2018;9:4255. doi: 10.1038/s41467-018-06748-3
Ngo TTM, Moufarrej MN, Rasmussen M-LH, Camunas-Soler J, Pan W, Okamoto J, Neff NF, Liu K, Wong RJ, Downes K, Tibshirani R, Shaw GM, Skotte L, Stevenson DK, Biggio JR, Elovitz MA, Melbye M*, Quake SR*. Noninvasive blood tests for fetal development predict gestational age and preterm delivery. (*shared last author) Science 2018; 360:1133-1136
Demenais F, Margaritte-Jeannin P, Barnes KC, ........ Melbye M, ........ Yang JH, Moffatt MF, Ober C, Nicolae DL. Multi-ancestry genome-wide association study identifies new asthma risk loci that colocalize with immune cell enhancer marks. Nat Genet 2018; Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7
Zhang G, Feenstra B, Bacelis J, ....., Melbye M, Jacobsson B, Muglia LJ. Genetic associations with gestational duration and spontaneous preterm birth. N Engl J Med 2017; DOI: 10.1056/NEJMoa1612665
Behrens I, Basit S, Lykke JA, Ranthe MF, Wohlfahrt J, Bundgaard H, Melbye M, Boyd HA. Association between hypertensive disorders of pregnancy and later risk of cardiomyopathy. JAMA 2016;315:1026-33 
Charlton BM, Mølgaard-Nielsen D, Svanström H, Wohlfahrt J, Pasternak B and Melbye M. Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study. BMJ 2016;352:doi:hhtp://dx.doi.org/10.1136/mbj.h6712
Mølgaard-Nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B. Association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth. JAMA 2016;315:58-67
Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard D, Schoggins JW, Jan LY, Melbye M and Hviid A. Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet 2014;46:1274-1282
Geller F, Feenstra B, Carstensen L, Pers TH, van Rooij IALM, Körberg IB, Choudhry S, Karjalainen J, Schnack T, Hollegaard MV, Feitz WFJ, Roeleveld N, Hougaard D, Hirschhorn JN, Franke L, Baskin LS, Nordenskjöld A, van der Zanden LFM, Melbye M. Genome-wide association analyses identify variants in developmental genes associated withy hypospadias. Nat Genet 2014;46:957-63 
Lund M, Pasternak B, Davidsen RB, Feenstra B, Krogh C, Wohlfahrt J and Melbye M. Use of macrolides in mother and child and risk of pyloric stenosis: Nationwide Cohort Study. BMJ 2014;348:g1908 
Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013;369:2406-15 
Feenstra B, Geller F, Carstensen L, Romitti PA, Körberg IB, Bedell B, Krogh C, Fan R, Svenningson A, Caggana M, Nordenskjöld A, Mills JL, Murray JC, Melbye M. Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis. JAMA 2013;310:714-21 
Feenstra B, Geller F, Krogh C, Hollegaard MV, Gørtz S, Boyd HA, Murray JC, Hougaard DM, Melbye M. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. Nat Genet 2012;44:334-7
Biggar RJ, Wohlfahrt J, Oudin A, Hjuler T, Melbye M. Digoxin use and the risk of breast cancer in women. J Clin Oncol 2011;29:2165-70 
Krogh C, Fischer TK, Skotte L, Biggar RJ, Øyen N, Skytthe A, Gørtz S, Christensen K, Wohlfahrt J, Melbye M. Familial aggregation and heritability of pyloric stenosis. JAMA 2010; 303:2393-2399 
Edgren G, Hjalgrim H, Reilly M, Tran TN, Rostgaard K, Shanwell A, Titlestad K, Adami J, Wikman A, Jersild C, Gridley G, Wideroff L, Nyrén O, Melbye M. Risk of cancer after blood transfusion from donors with subclinical cancer. Lancet 2007; 369:1724-1730 
Ahlgren M, Melbye M, Wohlfahrt J and Sørensen TIA. Growth patterns and risk of breast cancer. N Engl J Med 2004;351:1619-1626 
Madsen KM, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, Olsen J, Melbye M. A population-based study of measles, mumps and rubella vaccination and autism. N Engl J Med 2002; 347:1477-1482 
Mortensen PB, Pedersen CB, Westergaard T, Wohlfahrt J, Ewald H, Mors O, Andersen PK, Melbye M. Effects of family history and place and season at birth on the risk of schizophrenia. N Engl J Med 1999; 340:603-608
Frisch M, Glimelius B, van den Brule AJC, Wohlfahrt J, Meijer CJLM, Walboomers JMM, Adami HO, Melbye M. A sexually transmitted infection as a cause of anal cancer. N Engl J Med 1997; 337:1350-1358 
Melbye M, Wohlfahrt J, Olsen JH, Frisch M, Westergaard T, Larsen KH, Andersen PK. Induced abortion and the risk of breast cancer. N Engl J Med 1997; 336:81-85 
Melbye M, Sprøgel P. Aetiological parallel between anal cancer and cervical cancer. Lancet 1991; 338:657-659

Melbye M, Froebel K, Madhok R, Biggar RJ, Sarin P, Stenbjerg S, Lowe C, Forbes CD, Goedert JJ, Gallo RC, Ebbesen P. HTLV-III seropositivity in European haemophiliacs exposed to factor VIII concentrate imported from the USA. Lancet 1984; ii:1444-1446